SERCA's calcium pumping ability is reduced by the ERp57 chaperone.

ER chaperones need calcium to help them in their folding duties. Work on page 35 by Li and Camacho shows that some chaperones take a proactive stance on Ca2+ levels by regulating an ER Ca2+ pump.

Calcium must be pumped into the ER from the cytoplasm to maintain high levels for Ca2+-needy chaperones. This function is performed in many cells by the SERCA 2b pump. The authors show that some chaperones, in addition to helping newly synthesized proteins fold correctly, also inform SERCA 2b of the ER Ca2+ status. And what they have to say can alter pump activity.

High Ca2+ levels lowered pump activity by promoting an interaction between SERCA 2b and the chaperone ERp57, which catalyzed disulfide bridge formation in the lumenal portion of SERCA 2b. But...

The Rockefeller University Press
2004
The Rockefeller University Press
2004
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