Gross cerebellar structure is fine without LTD.
Using a conditional gene knock-out approach, the authors disrupted the expression of cGMP-dependent protein kinase type I (cGKI) in Purkinje cells, which normally express high levels of the kinase. The disruption virtually abolishes cerebellar LTD in the mutant mice, but the animals perform normally in several tests of motor coordination. However, adaptation of the vestibulo-ocular reflex of the mutant mice, which keeps images stable on the retina during head movements, is defective.
Feil et al. propose that cGKI links nitric oxide and cGMP...
The Rockefeller University Press
2003
The Rockefeller University Press
2003
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