Though normally cytoplasmic (left), cyclin B (red) targeted to the nucleus (right) can start S phase.
Hunt/AAAS
In frog egg extracts, S phase is induced in nuclei by Cdk2–cyclin E, but not by Cdk1–cyclin B. This difference has often been construed as specificity in cyclin substrate preferences, but the new results show that cyclin/Cdk pairs are in fact surprisingly promiscuous enzymes. Hunt's group simply replaced the nuclear export signal from cyclin B with a nuclear localization...
The Rockefeller University Press
2003
The Rockefeller University Press
2003
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