MgcRacGAP and RhoA colocalize at the midbody during cytokinesis.
Minoshima/Elsevier
When they first isolated MgcRacGAP, the group found that most of its activity was directed toward Rac1 and Cdc42, but there were hints—although inconsistent ones—that it also had activity toward Rho proteins. In the new work, Kitamura and colleagues found that, late in mitosis, Aurora B, RhoA, and MgcRacGAP congregate at the midbody, where Aurora B phosphorylates a serine in the GAP domain of MgcRacGAP. The phosphorylated GAP protein...
The Rockefeller University Press
2003
The Rockefeller University Press
2003
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