A COOH-terminal fragment (right) but not full-length (left) p115 induces apoptosis.
The authors found that the tethering protein p115, which is essential for maintaining normal Golgi apparatus architecture, is selectively cleaved during apoptosis. The apoptotic proteases caspase-3 and caspase-8 cleave the protein in vitro, and a stable cell line expressing a cleavage-resistant form of p115 exhibits a delay in Golgi fragmentation during apoptosis. Expressing the COOH-terminal cleavage fragment of p115...
The Rockefeller University Press
2002
The Rockefeller University Press
2002
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