c-Fos (green) is more stable (top to bottom) in PDGF-treated cells.
Blenis/Macmillan
Growth factors PDGF and EGF elicit different responses in fibroblasts, with only PDGF inducing cells to enter S-phase. The group found that EGF transiently activated ERK MAP kinases, whereas PDGF stimulated prolonged activation. The IEG product c-Fos is known to be transcribed with similar kinetics in response to either growth factor, but c-Fos was only phosphorylated when ERK activity was sustained. This not only stabilized c-Fos, but also primed...
The Rockefeller University Press
2002
The Rockefeller University Press
2002
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