CICR occurs after uncaging calcium at apical (red) but not basal (blue) locations.
Using spatially restricted uncaging of caged Ca2+, the authors were able to boost cytosolic Ca2+ concentrations in specific regions within pancreatic acinar cells. These cells ordinarily produce polarized Ca2+ waves after stimulation with an agonist. When caged Ca2+ uncaged in the apical region of the cells, a CICR wave spreads from the apical region toward the...
The Rockefeller University Press
2002
The Rockefeller University Press
2002
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