Philips/Macmillan
Ras (white) is activated on both the plasma membrane and the Golgi (left to right).
Ras GTPases are molecular switches that transduce mitogenic signals by activating downstream effectors, particularly in the MAPK pathway, when GTP is bound. Previous results have led to the belief that Ras is only active when bound to the cytosolic face of the plasma membrane. Several isoforms of human Ras exist, including K-Ras, N-Ras, and H-Ras, but the biological need for this diversity has been unclear. “If all three lead to MAPK activation, why have so many different isoforms?” says Philips. It has been hypothesized...
The Rockefeller University Press
2002
The Rockefeller University Press
2002
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