Cristae in crisis

Cristae, the complex involutions of the mitochondrial inner membrane, vastly increase the surface area across which ATP synthase can generate a proton gradient. Now, new findings from Jean Velours (Université Victor Ségalen, Bordeaux, France) and colleagues suggest that ATP synthase may be important in forming cristae in the first place.

Velours' theory is that oligomerization of ATP synthase in the mitochondrial inner membrane helps tubulate the membrane. This idea was first suggested based on the zippered rows of ATP synthase molecules visible on the cristae of Paramecium mitochondria. Velours does not yet know if yeast has the same arrangement. But in the new work he detects the formation of yeast ATP synthase oligomers biochemically. Loss of the nonessential e or g subunits of ATP synthase both disrupts oligomerization and...