Progenitor cells express either liver (green) or bile duct (red) markers.
Suzuki et al. have attempted to isolate liver stem cells before, but their isolation strategy fell short of allowing clonal analysis. Now they add one additional selection marker (cMet, the receptor for hepatocyte growth factor) and use cell sorting to achieve a 560-fold enrichment for hepatic colony-forming units in culture (H-CFU-Cs). These single cells do not express markers for either hepatocytes or...
The Rockefeller University Press
2002
The Rockefeller University Press
2002
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