Tmod overexpression (red, bottom) arrests filament extension before it reaches the M line.
The authors target the pointed end by transiently overexpressing the fly version of Tropomodulin (Tmod) in indirect flight muscles (IFM). If the Tmod is overexpressed during pupation when myofibrils are assembled, a central core of thin filaments is shorter than normal, which in the most serious cases results in adults that are unable to...
The Rockefeller University Press
2001
The Rockefeller University Press
2001
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