Old cells gone bad

The rising incidence of senescent cells during aging may promote cancer development, according to Judith Campisi (Lawrence Berkeley National Laboratory, Berkeley, CA) and colleagues. They propose that evolution may have selected a useful function for cellular senescence early in life—the switching-off of cells that are prone to becoming cancerous—without any consideration of how these cells might behave later on in life.It is not the senescent cells themselves that become cancerous, however. Rather, these fibroblast cells produce soluble factors, matrix, and perhaps cell-surface molecules that cause cocultured preneoplastic or neoplastic epithelial cells to proliferate and form tumors in nude mice. Cocultured primary epithelial cells are not affected.

The effect on proliferation may be an unwanted byproduct of the senescence expression program, which includes increased levels of an odd mixture of molecules. Only a...