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Volume 154, Issue 6
17 September 2001
Journal of Cell Biology Cover Image for Volume 154, Issue 6
Article Contents
Review| September 17 2001

Where is APC going?

Yuko Mimori-Kiyosue,
Yuko Mimori-Kiyosue
1KAN Research Institute, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8815, Japan
2Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8813, Japan
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Shoichiro Tsukita
Shoichiro Tsukita
2Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8813, Japan
3Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8315, Japan
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Author and Article Information
Yuko Mimori-Kiyosue
1KAN Research Institute, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8815, Japan
2Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8813, Japan
Shoichiro Tsukita
2Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8813, Japan
3Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8315, Japan
Address correspondence to Shoichiro Tsukita, Dept. of Cell Biology, Kyoto University Faculty of Medicine, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8315, Japan. Tel.: 81-75-753-4372. Fax: 81-75-753-4660. E-mail: [email protected]
*

Abbreviations used in this paper: APC, adenomatous polyposis coli; DGL, Drosophila discs large; GFP; green fluorescent protein.

Received: June 21 2001
Revision Received: August 09 2001
Accepted: August 09 2001
Online ISSN: 1540-8140
Print ISSN: 0021-9525
The Rockefeller University Press
2001
J Cell Biol (2001) 154 (6): 1105–1110.
https://doi.org/10.1083/jcb.200106113
Article history
Received:
June 21 2001
Revision Received:
August 09 2001
Accepted:
August 09 2001

Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/β-catenin signaling pathway. However, its connections to the cytoskeleton and microtubules in particular are becoming apparent, and the discovery of these new functions for APC is leading to a reevaluation of its role not only in tumorigenesis, but also in normal physiology.

The Rockefeller University Press
2001
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