Branching out: Arp2/3 (red and green) can nucleate branches from filaments of actin (pink).
Hanein/AAAS
Structural studies now add anew dimension to the discourse, supporting the side-binding, dendritic nucleation model. These studies provide visual evidence that the seven subunit actin-related protein (Arp) complex is not inserted into the mother filament during actin filament nucleation in Acanthamoeba castellanii and Saccharomyces cerevisiae. Additionally, and rather unexpectedly, imaging by electron cryomicroscopy provides evidence that the Arp2/3 complex undergoes a major conformational change during branch formation.
This rearrangement of the complex was “rather surprising...
The Rockefeller University Press
2001
The Rockefeller University Press
2001
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