Signaling from focal adhesions gets cells through G1.
Giancotti/Elsevier
When endothelial cells adhere to the extracellular matrix protein fibronectin, they can proliferate in response to growth factors. Adhesion to laminin, however, brings their cell cycles to a dead stop. Why? Given that the response depends on the composition of the extracellular matrix, Filippo Giancotti and his colleagues at the Memorial Sloan-Kettering Cancer Center (New York, NY) proposed in 1996 that progression through the cell cycle depends on signaling from a cell's particular repertoire of adhesion receptors called integrins.
Integrins do not act alone, however. “Our major hypothesis in the past few years has been that the integrins that are able to promote proliferation do so by cooperating with growth factor receptors,” says Giancotti. That control was thought to be exerted via the MAP kinase ERK, at the level of cyclin D1 transcription. The new paper,...
