Several small nuclear and cytoplasmic RNAs are synthesized by RNA polymerase (Pol) III as nascent transcripts that must then migrate through RNA processing, modification, and transport machinery on their trek to becoming mature, functional molecules. The first factor to interact with newly synthesized Pol III transcripts is the La protein. Evidence that this molecular chaperone accompanies precursor tRNAs through various RNA modification and processing events and facilitates the assembly of other transcripts into specific RNPs is reviewed. Although most La is nucleoplasmic, some is nucleolar, and several Pol III transcripts, including precursors of tRNAs, U6 small nuclear RNA (snRNA), RNase P RNA, and signal recognition particle (SRP) RNA, have recently been shown to move through the nucleolus. Modifications found previously on La-associated U6 snRNA, coupled with recent data, now suggest that these modifications occur in the nucleolus, while U6...
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14 May 2001
Review|
May 14 2001
La Protein and the Trafficking of Nascent RNA Polymerase III Transcripts
Richard J. Maraia
Richard J. Maraia
aLaboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
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Richard J. Maraia
aLaboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
Abbreviations used in this paper: CTD, COOH-terminal domain; NTD, NH2-terminal domain; NLS, nuclear localization signal; Pol, polymerase; snoRNA, small nucleolar RNA; snRNA, small nuclear RNA; SRP, signal recognition particle.
Received:
February 13 2001
Revision Requested:
March 26 2001
Accepted:
March 27 2001
Online ISSN: 1540-8140
Print ISSN: 0021-9525
© 2001 The Rockefeller University Press
2001
The Rockefeller University Press
J Cell Biol (2001) 153 (4): F13–F18.
Article history
Received:
February 13 2001
Revision Requested:
March 26 2001
Accepted:
March 27 2001
Citation
Richard J. Maraia; La Protein and the Trafficking of Nascent RNA Polymerase III Transcripts. J Cell Biol 14 May 2001; 153 (4): F13–F18. doi: https://doi.org/10.1083/jcb.153.4.F13
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