The human genome project reached a major milestone earlier this year, with the completion of a rough draft of the sequence (Pennisi 2000). An accessible catalog of all human genes could greatly accelerate the pace of breakthroughs in medical research by allowing global analyses of gene expression changes in a variety of developmental and pathological states. However, it has never been clear whether these types of analyses could be efficiently performed, or whether significant sets of important data would emerge from the study of large sets of genes. Many diseases arise from single gene mutations in which the corresponding protein products are known. Would knowledge of global gene expression changes add to our existing understanding of these monogenic disorders or lead to the development of treatments? A paper in this issue provides a test of these questions...
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11 December 2000
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December 11 2000
Muscular Dystrophy Meets the Gene Chip: New Insights into Disease Pathogenesis
Jeffrey S. Chamberlain
Jeffrey S. Chamberlain
aDepartment of Neurology, University of Washington School of Medicine, Seattle, Washington 98195
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Jeffrey S. Chamberlain
aDepartment of Neurology, University of Washington School of Medicine, Seattle, Washington 98195
Abbreviations used in this paper: DGC, dystrophin glycoprotein complex; DMD, Duchenne muscular dystrophy; LGMD, limb–girdle muscular dystrophy.
Received:
November 17 2000
Accepted:
November 17 2000
Online ISSN: 1540-8140
Print ISSN: 0021-9525
© 2000 The Rockefeller University Press
2000
The Rockefeller University Press
J Cell Biol (2000) 151 (6): F43–F46.
Article history
Received:
November 17 2000
Accepted:
November 17 2000
Citation
Jeffrey S. Chamberlain; Muscular Dystrophy Meets the Gene Chip: New Insights into Disease Pathogenesis. J Cell Biol 11 December 2000; 151 (6): F43–F46. doi: https://doi.org/10.1083/jcb.151.6.F43
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