Conventional kinesin is a highly processive motor that can take >100 steps along a microtubule before dissociating. Various lines of evidence have led to a model of hand over hand processive motion, in which the trailing head detaches and rebinds to the next open tubulin dimer site on the same protofilament, leading to an 8-nm movement of the center of mass (Svoboda and Block 1994; Hancock and Howard 1998). Biochemical evidence for an alternating mechanism in which the ATPase cycles on the two heads are out of phase (Hackney 1994; Ma and Taylor 1997; Gilbert et al. 1998) supports the hand over hand mechanism. Processivity is a competition between the detachment and rebinding of one head in order to take a step, and the rate of dissociation of the complex while only...
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27 November 2000
Review|
November 27 2000
Kinesin Processivity
Edwin W. Taylor,
Edwin W. Taylor
aDepartment of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611
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Gary G. Borisy
Gary G. Borisy
aDepartment of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611
Search for other works by this author on:
Edwin W. Taylor
aDepartment of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611
Gary G. Borisy
aDepartment of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611
Received:
November 01 2000
Accepted:
November 01 2000
Online ISSN: 1540-8140
Print ISSN: 0021-9525
© 2000 The Rockefeller University Press
2000
The Rockefeller University Press
J Cell Biol (2000) 151 (5): F27–F30.
Article history
Received:
November 01 2000
Accepted:
November 01 2000
Citation
Edwin W. Taylor, Gary G. Borisy; Kinesin Processivity. J Cell Biol 27 November 2000; 151 (5): F27–F30. doi: https://doi.org/10.1083/jcb.151.5.F27
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