The recent sequencing of the Drosophila genome as a collaborative effort between the Berkeley Drosophila Genome Project (BDGP) and Celera Genomics provides an unparalleled opportunity to assess the prevalence of human disease gene counterparts in the fly genome (Adams et al. 2000; Rubin et al. 2000). Previous surveys based upon limited data available during earlier phases of the sequencing project have suggested that >50%, and perhaps as many as 75%, of human disease genes are conserved in Drosophila (Banfi et al. 1996; Berkeley Drosophila Genome Project 1999; Pickeral et al. 2000). With the virtually complete sequence now in hand, we were able to perform a more comprehensive survey, resulting in the finding that 178 out of 287 human disease genes (62%) appear to be conserved in the fly (Rubin et al....
Skip Nav Destination
Article navigation
24 July 2000
Review|
July 24 2000
A Survey of Human Disease Gene Counterparts in the Drosophila Genome
Mark E. Fortini,
Mark E. Fortini
aDepartment of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
Search for other works by this author on:
Marian P. Skupski,
Marian P. Skupski
bCelera Genomics, Rockville, Maryland 20850
Search for other works by this author on:
Mark S. Boguski,
Mark S. Boguski
cNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894
Search for other works by this author on:
Iswar K. Hariharan
Iswar K. Hariharan
dMassachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129
Search for other works by this author on:
Mark E. Fortini
aDepartment of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
Marian P. Skupski
bCelera Genomics, Rockville, Maryland 20850
Mark S. Boguski
cNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894
Iswar K. Hariharan
dMassachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129
Abbreviations used in this paper: ATM, ataxia telangiectasia; ATR, ATM-related; BDGP, Berkeley Drosophila Genome Project; OMIM, Online Mendelian Inheritance in Man database; VWF, von Willebrand factor; WAS, Wiskott-Aldrich syndrome.
Received:
June 05 2000
Revision Requested:
June 26 2000
Accepted:
June 26 2000
Online ISSN: 1540-8140
Print ISSN: 0021-9525
© 2000 The Rockefeller University Press
2000
The Rockefeller University Press
J Cell Biol (2000) 150 (2): F23–F30.
Article history
Received:
June 05 2000
Revision Requested:
June 26 2000
Accepted:
June 26 2000
Citation
Mark E. Fortini, Marian P. Skupski, Mark S. Boguski, Iswar K. Hariharan; A Survey of Human Disease Gene Counterparts in the Drosophila Genome. J Cell Biol 24 July 2000; 150 (2): F23–F30. doi: https://doi.org/10.1083/jcb.150.2.F23
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionEmail alerts
Advertisement
Advertisement