The classical view of the nucleolus as solely committed to ribosome biosynthesis has been modified by recent studies pointing to additional roles for this nuclear domain. These newly recognized features include the nucleolar presence of several nonribosomal RNAs transcribed by RNA polymerase III, as well as nucleolar roles in gene silencing, cell cycle progression, and cellular senescence. The signal recognition particle (SRP) RNA, and several protein components of the SRP also recently have been detected in the nucleolus. Thus, the large and small ribosomal subunits, the 5S rRNA–ribonucleoprotein complex, and now the SRP, are known to be assembled in or pass through the nucleolus. These findings, together with the recent observations that some transfer RNA precursor molecules and the pretransfer RNA processing enzyme, RNase P, are also found in the nucleolus, raise the possibility that these translational components are...
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20 March 2000
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March 20 2000
The Nucleolus and the Four Ribonucleoproteins of Translation
Thoru Pederson,
Thoru Pederson
aDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachussetts 01605
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Joan C. Politz
Joan C. Politz
aDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachussetts 01605
Search for other works by this author on:
Thoru Pederson
aDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachussetts 01605
Joan C. Politz
aDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachussetts 01605
Abbreviations used in this paper: GFP, green fluorescent protein; SRP, signal recognition particle.
Received:
January 21 2000
Revision Requested:
January 21 2000
Accepted:
February 09 2000
Online ISSN: 1540-8140
Print ISSN: 0021-9525
© 2000 The Rockefeller University Press
2000
The Rockefeller University Press
J Cell Biol (2000) 148 (6): 1091–1096.
Article history
Received:
January 21 2000
Revision Requested:
January 21 2000
Accepted:
February 09 2000
Citation
Thoru Pederson, Joan C. Politz; The Nucleolus and the Four Ribonucleoproteins of Translation. J Cell Biol 20 March 2000; 148 (6): 1091–1096. doi: https://doi.org/10.1083/jcb.148.6.1091
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