The structure of the lining cells at the surface of the synovial membrane facing the joint cavity has been studied by electron microscopy. The long cytoplasmic processes of these cells appear to be oriented toward the surface of the membrane, where they overlap and intertwine. The matrix of the lining cells contains dense material but no fibers with the periodicity of collagen. The lining cells are divided into two cell types or states of activity on the basis of their cytoplasmic contents. Type A is more numerous and contains a prominent Golgi apparatus, numerous vacuoles (0.4 to 1.5 microns in diameter) containing varying amounts of a dense granular material, many filopodia, mitochondria, intracellular fibrils, and micropinocytotic-like vesicles. Type B contains large amounts of ergastoplasm with fewer large vacuoles, micropinocytotic-like vesicles, and mitochondria. The probable functions of these cells are discussed in the light of current knowledge of the metabolism and function of the synovial membrane.
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1 August 1962
Article|
August 01 1962
ELECTRON MICROSCOPY OF THE HUMAN SYNOVIAL MEMBRANE
Peter Barland,
Peter Barland
From the Departments of Pathology and Medicine, Albert Einstein College of Medicine, New York
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Alex B. Novikoff,
Alex B. Novikoff
From the Departments of Pathology and Medicine, Albert Einstein College of Medicine, New York
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David Hamerman
David Hamerman
From the Departments of Pathology and Medicine, Albert Einstein College of Medicine, New York
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Peter Barland
From the Departments of Pathology and Medicine, Albert Einstein College of Medicine, New York
Alex B. Novikoff
From the Departments of Pathology and Medicine, Albert Einstein College of Medicine, New York
David Hamerman
From the Departments of Pathology and Medicine, Albert Einstein College of Medicine, New York
Received:
January 05 1962
Online ISSN: 1540-8140
Print ISSN: 0021-9525
Copyright, 1962, by The Rockefeller Institute Press
1962
J Cell Biol (1962) 14 (2): 207–220.
Article history
Received:
January 05 1962
Citation
Peter Barland, Alex B. Novikoff, David Hamerman; ELECTRON MICROSCOPY OF THE HUMAN SYNOVIAL MEMBRANE . J Cell Biol 1 August 1962; 14 (2): 207–220. doi: https://doi.org/10.1083/jcb.14.2.207
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