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Journal Articles

Prepulse facilitation of the honeybee Ca_V4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Thierry Cens, Matthieu Rousset, Claudine Menard, Mohamed Chahine, Claude Collet, Jean-Christophe Sandoz, Alain Chavanieu, Sebastien Estaran, Jean-Baptiste Thibaud, Patrick Bois, Pierre Charnet

J Gen Physiol (2026) 158 (2): e202413712.

https://doi.org/10.1085/jgp.202413712

Published: 10 February 2026

View article titled, Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Journal Articles

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Luca M.G. Palloni, Nicole Sarno, Caterina Azzoni, Nicol Furia, Matteo E. Mangoni, Alessandro Porro, Teresa Neeman, Andrea Saponaro, Gerhard Thiel, Anna Moroni, Dario DiFrancesco

J Gen Physiol (2026) 158 (2): e202513873.

https://doi.org/10.1085/jgp.202513873

Published: 06 February 2026

View article titled, AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Includes: Supplementary data

Journal Articles

Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current

Antonella Dapino, Sebastián Curti

J Gen Physiol (2026) 158 (2): e202513883.

https://doi.org/10.1085/jgp.202513883

Published: 30 January 2026

View article titled, Coincidence detection supported by electrical synapses is shaped by the D-type K+ current

Includes: Supplementary data

Journal Articles

A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations

Anthony L. Hessel, Katelyn M. Manross, Matthew M. Borkowski, Christopher D. Rand, Khoi Nguyen

J Gen Physiol (2026) 158 (2): e202513773.

https://doi.org/10.1085/jgp.202513773

Published: 28 January 2026

View article titled, A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations

Journal Articles

The relationship between apparent potentiation and the magnitude of the control response

Joe Henry Steinbach, Gustav Akk

J Gen Physiol (2026) 158 (2): e202513894.

https://doi.org/10.1085/jgp.202513894

Published: 27 January 2026

View article titled, The relationship between apparent potentiation and the magnitude of the control response

Journal Articles

Inhibition of Ca_V1.4 channels by Ca_V3 channel antagonists ML218 and Z944

Jinglang Sun, Juan de la Rosa Vázquez, Adriana Hernández-González, Vladimir Yarov-Yarovoy, Amy Lee

J Gen Physiol (2026) 158 (2): e202513879.

https://doi.org/10.1085/jgp.202513879

Published: 05 January 2026

View article titled, Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944

Includes: Supplementary data

Journal Articles

Manganese and intracellular Ca²⁺ handling

Godfrey L. Smith, David A. Eisner

J Gen Physiol (2025) 158 (2): e202513908.

https://doi.org/10.1085/jgp.202513908

Published: 26 December 2025

View article titled, Manganese and intracellular Ca2+ handling

Journal Articles

A critical residue mediates proper assembly and gating of GIRK2 channels

Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger

J Gen Physiol (2025) 158 (1): e202513817.

https://doi.org/10.1085/jgp.202513817

Published: 19 December 2025

View article titled, A critical residue mediates proper assembly and gating of GIRK2 channels

Includes: Supplementary data

Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy

J Gen Physiol (2025) 158 (2): e202413705.

https://doi.org/10.1085/jgp.202413705

Published: 18 December 2025

View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Includes: Supplementary data

Journal Articles

Ca_vβ dances the two-step with VSD II

Ben Short

J Gen Physiol (2025) 158 (1): e202513935.

https://doi.org/10.1085/jgp.202513935

Published: 18 December 2025

View article titled, Cavβ dances the two-step with VSD II

Journal Articles

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rios

J Gen Physiol (2025) 158 (1): e202513877.

https://doi.org/10.1085/jgp.202513877

Published: 17 December 2025

View article titled, Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Journal Articles

On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC

Hridya Valia Madapally, Adel Hussein, Martin Wazar Eriksen, Bjørn Panyella Pedersen, David L. Stokes, Himanshu Khandelia

J Gen Physiol (2025) 158 (1): e202513794.

https://doi.org/10.1085/jgp.202513794

Published: 12 December 2025

View article titled, On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

Includes: Supplementary data

Journal Articles

Towards a unified gating scheme for the CNBD ion channel family

Jenna L. Lin, Baron Chanda

J Gen Physiol (2025) 158 (1): e202513849.

https://doi.org/10.1085/jgp.202513849

Published: 11 December 2025

View article titled, Towards a unified gating scheme for the CNBD ion channel family

Includes: Supplementary data

Journal Articles

Novel binding mode for negative allosteric NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen

J Gen Physiol (2025) 158 (1): e202513872.

https://doi.org/10.1085/jgp.202513872

Published: 03 December 2025

View article titled, Novel binding mode for negative allosteric NMDA receptor modulators

Includes: Supplementary data

Journal Articles

Subtype-selective targeting of NMDA receptors—A potent new compound emerges

Hiro Furukawa

J Gen Physiol (2025) 158 (1): e202513920.

https://doi.org/10.1085/jgp.202513920

Published: 03 December 2025

View article titled, Subtype-selective targeting of NMDA receptors—A potent new compound emerges

Journal Articles

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb

J Gen Physiol (2025) 158 (1): e202513835.

https://doi.org/10.1085/jgp.202513835

Published: 02 December 2025

View article titled, Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Includes: Supplementary data

Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle

J Gen Physiol (2025) 158 (1): e202513890.

https://doi.org/10.1085/jgp.202513890

Published: 25 November 2025

View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels

Journal Articles

Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility

Alejandro Alvarez-Arce, Geena E. Fritzmann, Hope V. Burnham, Kelly N. Araujo, Alexandra Peña, Lucas M. Wittenkeller, Hannah E. Cizauskas, David Y. Barefield

J Gen Physiol (2025) 158 (1): e202413630.

https://doi.org/10.1085/jgp.202413630

Published: 19 November 2025

View article titled, Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility

Includes: Supplementary data

Journal Articles

Optical control of PI(4,5)P₂ sensitivity of ion channels by manipulation of single lysine residue

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura

J Gen Physiol (2025) 158 (1): e202513811.

https://doi.org/10.1085/jgp.202513811

Published: 18 November 2025

View article titled, Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue

Includes: Supplementary data

Journal Articles

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard

J Gen Physiol (2025) 158 (1): e202513800.

https://doi.org/10.1085/jgp.202513800

Published: 11 November 2025

View article titled, Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

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Prepulse facilitation of the honeybee Ca_V4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current

A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations

The relationship between apparent potentiation and the magnitude of the control response

Inhibition of Ca_V1.4 channels by Ca_V3 channel antagonists ML218 and Z944

Manganese and intracellular Ca²⁺ handling

A critical residue mediates proper assembly and gating of GIRK2 channels

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Ca_vβ dances the two-step with VSD II

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC

Towards a unified gating scheme for the CNBD ion channel family

Novel binding mode for negative allosteric NMDA receptor modulators

Subtype-selective targeting of NMDA receptors—A potent new compound emerges

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

β2 and β3a regulatory subunits can coassemble in the same BK channels

Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility

Optical control of PI(4,5)P₂ sensitivity of ion channels by manipulation of single lysine residue

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

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