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Shan Chen
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Journal Articles

Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis

Xiu-xiu Liu, Lin Yang, Ling-xiao Shao, Yang He, Gang Wu, Yu-huan Bao, Nan-nan Lu, Dong-mei Gong, Ya-ping Lu, Tian-tian Cui, Ning-he Sun, Dan-yang Chen, Wei-xing Shi, Kohji Fukunaga, Hong-shan Chen, Zhong Chen, Feng Han, Ying-mei Lu
Journal: Journal of Experimental Medicine
J Exp Med (2019) 217 (1): e20180992.
https://doi.org/10.1084/jem.20180992
Published: 07 November 2019
View article titled, Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis
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Includes: Supplementary data
Journal Articles

Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations

In Special Collection:
Electrical Signaling in the Nervous System and Heart , Ion channel modulation , Structure, Function, and Pharmacology of Ion Channels
Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen, Kenichiro Handa, Yuko Yamakawa, Jon T. Sack, Yoshihisa Kurachi
Journal: Journal of General Physiology
J Gen Physiol (2019) 151 (2): 214–230.
https://doi.org/10.1085/jgp.201812192
Published: 23 January 2019
View article titled, Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations
Open the PDF for Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations in another window
Includes: Supplementary data
Journal Articles

Voltage Sensor Movement and cAMP Binding Allosterically Regulate an Inherently Voltage-independent Closed−Open Transition in HCN Channels

Shan Chen, Jing Wang, Lei Zhou, Meena S. George, Steven A. Siegelbaum
Journal: Journal of General Physiology
J Gen Physiol (2007) 129 (2): 175–188.
https://doi.org/10.1085/jgp.200609585
Published: 29 January 2007
View article titled, Voltage Sensor Movement and cAMP Binding Allosterically Regulate an Inherently Voltage-independent Closed−Open Transition in HCN Channels
Open the PDF for Voltage Sensor Movement and cAMP Binding Allosterically Regulate an Inherently Voltage-independent Closed−Open Transition in HCN Channels in another window
Includes: Supplementary data
Journal Articles

Regulation of Hyperpolarization-Activated Hcn Channel Gating and Camp Modulation Due to Interactions of Cooh Terminus and Core Transmembrane Regions

Jing Wang, Shan Chen, Steven A. Siegelbaum
Journal: Journal of General Physiology
J Gen Physiol (2001) 118 (3): 237–250.
https://doi.org/10.1085/jgp.118.3.237
Published: 13 August 2001
View article titled, Regulation of Hyperpolarization-Activated Hcn Channel Gating and Camp Modulation Due to Interactions of Cooh Terminus and Core Transmembrane Regions
Open the PDF for Regulation of Hyperpolarization-Activated Hcn Channel Gating and Camp Modulation Due to Interactions of Cooh Terminus and Core Transmembrane Regions in another window
Journal Articles

Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

Shan Chen, Jing Wang, Steven A. Siegelbaum
Journal: Journal of General Physiology
J Gen Physiol (2001) 117 (5): 491–504.
https://doi.org/10.1085/jgp.117.5.491
Published: 30 April 2001
View article titled, Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide
Open the PDF for Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide in another window