Structure, Function, and Pharmacology of Ion Channels

This collection provides fundamental insights into the structure, function and pharmacology of a number of different ligand- and voltage-gated ion channels, which will ultimately support the development of new and specific drugs to target monogenic, multigenic, and acquired disease.

Ion channels are transmembrane proteins that are critical components of both excitable and non-excitable cells. Without ion channels, neurons would not be able to communicate with other cells, muscle would not be able to contract and our immune system would not be able to fight infection. Indeed, when ion channels go awry, disease often follows.

Image © 2019 Fryatt et al.