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Research Letter
Multigenerational SOCS1 insufficiency: Implications for the pathogenesis of allergic and autoimmune disease
This letter highlights diagnostic importance of considering monogenic immune dysregulation in complex allergic and autoimmune diseases. Additionally, the report expands on the clinical spectrum of suppressor of cytokine signaling 1 insufficiency (SOCS1 insufficiency) by identifying severe, treatment-refractory eosinophilic asthma as a novel primary manifestation.
Kawasaki disease complicated by macrophage activation syndrome treated with canakinumab
Netea et al. present an infant with macrophage activation syndrome as part of Kawasaki disease, who was first treated with canakinumab, followed by methylprednisolone and IVIG. Despite early treatment, giant coronary artery aneurysms developed transiently, questioning the singular role of IL-1 in KD.
