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Journal Articles

Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression

Lucian Medrihan, Margarete G. Knudsen, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa, Paul Greengard, Ana Milosevic
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413693.
https://doi.org/10.1085/jgp.202413693
Published: 07 March 2025
View articletitled, Projections from ventral hippocampus to nucleus accumbens’ cholinergic neurons are altered in depression
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Journal Articles

Mechanisms underlying the distinct K+ dependencies of periodic paralysis

Brent D. Foy, Chris Dupont, Phillip V. Walker, II, Kirsten Denman, Kathrin L. Engisch, Mark M. Rich
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413610.
https://doi.org/10.1085/jgp.202413610
Published: 04 February 2025
View articletitled, Mechanisms underlying the distinct K+ dependencies of periodic paralysis
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Includes: Supplementary data
Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413669.
https://doi.org/10.1085/jgp.202413669
Published: 17 January 2025
View articletitled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels
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Includes: Supplementary data
Journal Articles

Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy

Jonathan Schreiber, Ludivine Rotard, Yves Tourneur, Aude Lafoux, Christine Berthier, Bruno Allard, Corinne Huchet, Vincent Jacquemond
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413588.
https://doi.org/10.1085/jgp.202413588
Published: 24 December 2024
View articletitled, Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy
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Journal Articles

Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency

Amy D. Hanna, Ting Chang, Kevin S. Ho, Rachel Sue Zhen Yee, William Cameron Walker, Nadia Agha, Chih-Wei Hsu, Sung Yun Jung, Mary E. Dickinson, Md. Abul Hassan Samee, Christopher S. Ward, Chang Seok Lee, George G. Rodney, Susan L. Hamilton
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413583.
https://doi.org/10.1085/jgp.202413583
Published: 11 December 2024
View articletitled, Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency
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Includes: Supplementary data
Journal Articles

Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1

Mathilde Dubois, Florian Pallot, Maxime Gouin-Gravezat, Doria Boulghobra, Florence Coste, Guillaume Walther, Gregory Meyer, Isabelle Bornard, Cyril Reboul
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313485.
https://doi.org/10.1085/jgp.202313485
Published: 07 November 2024
View articletitled, Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1
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Includes: Supplementary data
Journal Articles

Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain

Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (11): e202413596.
https://doi.org/10.1085/jgp.202413596
Published: 08 October 2024
View articletitled, Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain
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Includes: Supplementary data
Journal Articles

A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function

Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313502.
https://doi.org/10.1085/jgp.202313502
Published: 20 September 2024
View articletitled, A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function
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Journal Articles

An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities

Lina Kraujaliene, Tadas Kraujalis, Mindaugas Snipas, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413600.
https://doi.org/10.1085/jgp.202413600
Published: 20 September 2024
View articletitled, An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities
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Includes: Supplementary data
Journal Articles

A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice

Sofia Benucci, Alexis Ruiz, Martina Franchini, Lucia Ruggiero, Dario Zoppi, Rebecca Sitsapesan, Chris Lindsay, Pawel Pelczar, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313486.
https://doi.org/10.1085/jgp.202313486
Published: 04 March 2024
View articletitled, A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice
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Includes: Supplementary data
Journal Articles

Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy

Ricardo A. Galli, Tamara C. Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T. Hwee, Fady I. Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M. de Winter, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313471.
https://doi.org/10.1085/jgp.202313471
Published: 20 February 2024
View articletitled, Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy
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Includes: Supplementary data
Journal Articles

Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models

In Special Collection:
Neuroscience Collection 2024
Ria L. Dinsdale, Cooper E. Roache, Andrea L. Meredith
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (11): e202313357.
https://doi.org/10.1085/jgp.202313357
Published: 20 September 2023
View articletitled, Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models
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Includes: Supplementary data
Journal Articles

Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties

In Special Collection:
Biophysics 2024 , Molecular Insights into Membrane Protein Function , Neuroscience Collection 2023
Christopher H. Thompson, Franck Potet, Tatiana V. Abramova, Jean-Marc DeKeyser, Nora F. Ghabra, Carlos G. Vanoye, John J. Millichap, Alfred L. George, Jr
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (10): e202313375.
https://doi.org/10.1085/jgp.202313375
Published: 14 August 2023
View articletitled, Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties
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Includes: Supplementary data
Journal Articles

The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart

Amy M. Dorward, Alan J. Stewart, Samantha J. Pitt
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (7): e202213206.
https://doi.org/10.1085/jgp.202213206
Published: 16 June 2023
View articletitled, The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart
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Journal Articles

Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias

Mauricio A. Lillo, Manuel Muñoz, Paula Rhana, Kelli Gaul-Muller, Jonathan Quan, Natalia Shirokova, Lai-Hua Xie, Luis Fernando Santana, Diego Fraidenraich, Jorge E. Contreras
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (7): e202213150.
https://doi.org/10.1085/jgp.202213150
Published: 16 May 2023
View articletitled, Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias
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Includes: Supplementary data
Journal Articles

Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure

Sukriti Dewan, Namthip Witayavanitkul, Mohit Kumar, Beth J. Mayer, Lauren Betancourt, Olivier Cazorla, Pieter P. de Tombe
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (6): e202213288.
https://doi.org/10.1085/jgp.202213288
Published: 27 April 2023
View articletitled, Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure
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Includes: Supplementary data
Journal Articles

Eccentric contraction-induced strength loss in dystrophin-deficient muscle: Preparations, protocols, and mechanisms

Leonit Kiriaev, Cory W. Baumann, Angus Lindsay
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (2): e202213208.
https://doi.org/10.1085/jgp.202213208
Published: 18 January 2023
View articletitled, Eccentric contraction-induced strength loss in dystrophin-deficient muscle: Preparations, protocols, and mechanisms
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Journal Articles

Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension

Yong-Xiao Wang, Jorge Reyes-García, Annarita Di Mise, Yun-Min Zheng
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2023) 155 (3): e202213100.
https://doi.org/10.1085/jgp.202213100
Published: 10 January 2023
View articletitled, Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension
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Journal Articles

Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols

Da-Jeong Jeong, Kwon-Woo Kim, Byung-Chang Suh
Journal: Journal of General Physiology
J Gen Physiol (2022) 155 (2): e202213191.
https://doi.org/10.1085/jgp.202213191
Published: 19 December 2022
View articletitled, Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols
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Journal Articles

Huntingtin regulates calcium fluxes in skeletal muscle

Mathilde Chivet, Maximilian McCluskey, Anne Sophie Nicot, Julie Brocard, Mathilde Beaufils, Diane Giovannini, Benoit Giannesini, Brice Poreau, Jacques Brocard, Sandrine Humbert, Frédéric Saudou, Julien Fauré, Isabelle Marty
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2022) 155 (1): e202213103.
https://doi.org/10.1085/jgp.202213103
Published: 21 November 2022
View articletitled, Huntingtin regulates calcium fluxes in skeletal muscle
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Includes: Supplementary data