Ion Channels in Health and Disease
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Journal Articles

A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function

Augustus J. Lowry, Pengfei Liang, Maria A. Gonzalez Torres, Huanghe Yang
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202614003.
https://doi.org/10.1085/jgp.202614003
Published: 10 August 2026
View article titled, A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function
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Journal Articles

Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies

Kate M. Crowther, Thibault R.H. Jouen-Tachoire, Peter Proks, Peter Rory Hall, Emma L. Veale, Janina Sörmann, Karin E.J. Rödström, Thomas Müller, Saskia B. Wortmann, Nina Barisic, Natalie Hauser, Vincenzo Salpietro, RaeLynn Forsyth, Linford Williams, Nora Derrabi, Carlos A. Bacino, Jill A. Rosenfeld, Henry Houlden, Simon Newstead, Caroline F. Wright, James Fasham, Alistair A. Mathie, Reza Maroofian, Stephen J. Tucker
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202613989.
https://doi.org/10.1085/jgp.202613989
Published: 06 August 2026
View article titled, Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies
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Includes: Supplementary data
Journal Articles

Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes

Arpan Bysack, H. Raghuraman
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202614000.
https://doi.org/10.1085/jgp.202614000
Published: 06 August 2026
View article titled, Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes
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Includes: Supplementary data
Journal Articles

Evolution, hibernation, and inactivation of voltage-gated Na channels

John S. Willis
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202513923.
https://doi.org/10.1085/jgp.202513923
Published: 07 July 2026
View article titled, Evolution, hibernation, and inactivation of voltage-gated Na channels
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Journal Articles

An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect

Jerome Clatot, Hubert Monnerie, Axel Panzer, Konrad Platzer, Ethan M. Goldberg
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202513962.
https://doi.org/10.1085/jgp.202513962
Published: 25 June 2026
View article titled, An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect
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Journal Articles

Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue

Richard D. Rainbow, Richard Barrett-Jolley
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (4): e202614036.
https://doi.org/10.1085/jgp.202614036
Published: 15 June 2026
View article titled, Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue
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Journal Articles

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Magalí Colomer-Molera, Daniel Sastre, Antonio Felipe
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (4): e202513936.
https://doi.org/10.1085/jgp.202513936
Published: 20 May 2026
View article titled, Structural determinants at KCNE4 position 145 govern Kv1.3 channel function
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Includes: Supplementary data
Journal Articles

Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue

Rosa Scala, Yuezhou Chen, Berk Mizrak, Gretchen A. Meyer, Colin G. Nichols
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (4): e202613986.
https://doi.org/10.1085/jgp.202613986
Published: 20 May 2026
View article titled, Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue
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Journal Articles

Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles

Manuel F. Muñoz, Collin Matsumoto, Paula Rhana, Declan Manning, Geoanna M. Bautista, Daniel M. Collier, L. Fernando Santana
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (3): e202513874.
https://doi.org/10.1085/jgp.202513874
Published: 31 March 2026
View article titled, Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles
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Journal Articles

Coincidence detection supported by electrical synapses is shaped by the D-type K+ current

Antonella Dapino, Sebastián Curti
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (2): e202513883.
https://doi.org/10.1085/jgp.202513883
Published: 30 January 2026
View article titled, Coincidence detection supported by electrical synapses is shaped by the D-type K+ current
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Includes: Supplementary data
Journal Articles

SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1

Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K. Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D. Gada, Takeharu Kawano, Meng Cui, Leigh D. Plant
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513837.
https://doi.org/10.1085/jgp.202513837
Published: 14 October 2025
View article titled, SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1
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Includes: Supplementary data
Journal Articles

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

Rosa Scala, Maya Mukadam, Yuezhou Chen, Courtney Frazier, Nathaniel W. York, Robert C. Tryon, Gretchen A. Meyer, Colin G. Nichols
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513781.
https://doi.org/10.1085/jgp.202513781
Published: 07 October 2025
View article titled, Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice
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