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ON THE COVER
Simulated pyramidal neuron action potential firing performed for two developmental stages featuring wild-type or epilepsy-associated NaV1.2 variants expressed at different ratios of neonatal and adult NaV1.2 splice isoforms. Variants associated with early-onset epileptic encephalopathy exhibit greater dysfunction in the neonatal splice isoform, and confer neuronal hyperexcitability in immature neurons where neonatal NaV1.2 is the predominant splice isoform. Image © Thompson et al., 2020. See http://doi.org/10.1085/jgp.201912442 - PDF Icon PDF LinkTable of Contents
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Research News
How stomatin stops ASIC3 gating
JGP study suggests that stomatin may trap the acid-sensing ASIC3 channel in its desensitized state.
Review
Structural mechanisms of transient receptor potential ion channels
Cao synthesizes data from TRP channel structures that have resulted from the “resolution revolution” in cryo-EM.
Research Articles
Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin
The integral membrane protein stomatin inhibits the gating of acid-sensing ion channels by an unknown mechanism. Klipp et al. suggest that stomatin binds to the C-terminus of ASIC3 and stabilizes the desensitized state via an interaction with the channels’ first transmembrane domain.
Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants
Early-onset epileptic encephalopathy (EOEE) is associated with variants in the SCN2A gene encoding the voltage-gated sodium channel NaV1.2. Thompson et al. reveal that several of these variants have a greater effect on channel function and neuronal excitability when present in neonatal splice isoforms.
Communication
Membrane conductances of mouse cone photoreceptors
Ingram et al. identify and characterize the membrane conductance properties of mouse cone photoreceptors, including the light-dependent conductance in the outer segment and voltage-dependent and Ca2+-activated conductances in the cone inner segment, which shape the voltage response to light.
