Early-onset epileptic encephalopathy (EOEE) is associated with variants in the SCN2A gene encoding the voltage-gated sodium channel NaV1.2. Thompson et al. reveal that several of these variants have a greater effect on channel function and neuronal excitability when present in neonatal splice isoforms.
Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin
The integral membrane protein stomatin inhibits the gating of acid-sensing ion channels by an unknown mechanism. Klipp et al. suggest that stomatin binds to the C-terminus of ASIC3 and stabilizes the desensitized state via an interaction with the channels’ first transmembrane domain.
Ingram et al. identify and characterize the membrane conductance properties of mouse cone photoreceptors, including the light-dependent conductance in the outer segment and voltage-dependent and Ca2+-activated conductances in the cone inner segment, which shape the voltage response to light.