1 September 2011
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Cover Image
Cover Image
Cover picture: Modification of the cytoplasmic, carboxyl-terminal domain (CT) of connexin26 affects modulation of channel activity by taurine (left, from top: orbital structure, electrostatic potential, local ionization potential). Energy-minimized conformations of the native CT (center) with a four amino acid addition (right) are shown. NMR shows that taurine interacts only with the cytoplasmic loop domain (CL), not the CT. In the presence of taurine, the pore closes; the four amino acid extension causes pore narrowing. Results suggest that CL–CT interaction affects gating, and that taurine modifies this interaction (see article by Locke et al., 321–339).
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ISSN 0022-1295
EISSN 1540-7748
Perspective
Perspectives on: Information and coding in mammalian sensory physiology
Nonlinear spatial encoding by retinal ganglion cells: when 1 + 1 ≠ 2
Perspectives on: Information and coding in mammalian sensory physiology
Probing mammalian touch transduction
Perspectives on: Information and coding in mammalian sensory physiology
Response kinetics of olfactory receptor neurons and the implications in olfactory coding
Perspectives on: Information and coding in mammalian sensory physiology
