A realistic model of a fixed-charge membrane was constructed to elucidate the principles involved in the Teorell-Meyer-Sievers theory. Polyelectrolyte solutions (polystyrene sulfonic acid or gelatin) were used in a multicompartment cell to serve as the "membrane." The ionic concentration and potential differences between the compartments served as a finite increment approximation to a continuous membrane phase. The profiles obtained for a positively and negatively charged membrane gave striking support for the theory.
REALISTIC MODEL OF A FIXED-CHARGE MEMBRANE ACCORDING TO THE THEORY OF TEORELL, MEYER, AND SIEVERS
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Alexander Mauro, Alan Finkelstein; REALISTIC MODEL OF A FIXED-CHARGE MEMBRANE ACCORDING TO THE THEORY OF TEORELL, MEYER, AND SIEVERS . J Gen Physiol 20 November 1958; 42 (2): 385–391. doi: https://doi.org/10.1085/jgp.42.2.385
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