Lymphocytes comprise two major subsets, T and B cells. Some T cells kill infected cells, while others help B cells produce antibodies. Deciphering the interactions between these cells and other cells is crucial to the development of therapeutics and vaccines.
Our understanding of the generation and function of B lymphocytes is well represented by publications in JEM , including numerous landmark studies on normal B cell immunology. This viewpoint reflects on a selection of such high-impact studies.
Th17 cells were born as a new subset of CD4 T cells to complement Th1, Th2, and T reg cells. From their identification as a distinct subset, they quickly became the paradigm for the astonishing plasticity that CD4 T cells can exhibit depending on tissue environment and circumstances.