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The Inflammasomes: From Mechanism to Therapeutics

A collection of novel mechanisms of inflammasome regulation and the role of inflammasomes in inflammation, cancer and immune defense. Articles featured in the collection were published within the past 12 months and have been selected based on usage, relevance, and level of discussion on social media. We hope you enjoy reading the collection, and encourage your feedback on Twitter at @JExpMed. To learn more about JEM and to submit your research, please visit our Instructions for Authors or contact the editorial office. Sign up to receive future special collections here.

Image © 2020 Megli et al.

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Zsófia Agnes Bittner; Xiao Liu; Maria Mateo Tortola; Ana Tapia-Abellán; Sangeetha Shankar; Liudmila Andreeva; Matthew Mangan; Marianne Spalinger; Hubert Kalbacher; Peter Düwell; Marta Lovotti; Karlotta Bosch; Sabine Dickhöfer; Ana Marcu; Stefan Stevanović; Franziska Herster; Yamel Cardona Gloria; Tzu-Hsuan Chang; Francesca Bork; Carsten L. Greve; Markus W. Löffler; Olaf-Oliver Wolz; Nadine A. Schilling; Jasmin B. Kümmerle-Deschner; Samuel Wagner; Anita Delor; Bodo Grimbacher; Oliver Hantschel; Michael Scharl; Hao Wu; Eicke Latz; Alexander N.R. Weber
DOI: 10.1084/jem.20201656
Julien Stackowicz; Nicolas Gaudenzio; Nadine Serhan; Eva Conde; Ophélie Godon; Thomas Marichal; Philipp Starkl; Bianca Balbino; Axel Roers; Pierre Bruhns; Friederike Jönsson; Philippe Moguelet; Sophie Georgin-Lavialle; Lori Broderick; Hal M. Hoffman; Stephen J. Galli; Laurent L. Reber
DOI: 10.1084/jem.20201466
Shuhang Li; Linlin Wang; Zhihao Xu; Yuanyuan Huang; Rufeng Xue; Ting Yue; Linfeng Xu; Fanwu Gong; Shiyu Bai; Qielan Wu; Jiwei Liu; Bolong Lin; Huimin Zhang; Yanhong Xue; Pingyong Xu; Junjie Hou; Xiaofei Yang; Tengchuan Jin; Rongbin Zhou; Jizhong Lou; Tao Xu; Li Bai
DOI: 10.1084/jem.20202637
Keitaro Fukuda; Ken Okamura; Rebecca L. Riding; Xueli Fan; Khashayar Afshari; Nazgol-Sadat Haddadi; Sean M. McCauley; Mehmet H. Guney; Jeremy Luban; Takeru Funakoshi; Tomonori Yaguchi; Yutaka Kawakami; Anastasia Khvorova; Katherine A. Fitzgerald; John E. Harris
DOI: 10.1084/jem.20200962
Oyebola O. Oyesola; Michael T. Shanahan; Matt Kanke; Bridget M. Mooney; Lauren M. Webb; Shuchi Smita; Macy K. Matheson; Pamela Campioli; Duc Pham; Simon P. Früh; John W. McGinty; Madeline J. Churchill; Jordan L. Cahoon; Pavithra Sundaravaradan; Becca A. Flitter; Karthik Mouli; Marija S. Nadjsombati; Elena Kamynina; Seth A. Peng; Rebecca L. Cubitt; Karsten Gronert; James D. Lord; Isabella Rauch; Jakob von Moltke; Praveen Sethupathy; Elia D. Tait Wojno
DOI: 10.1084/jem.20202178
Tamara S. Rodrigues; Keyla S.G. de Sá; Adriene Y. Ishimoto; Amanda Becerra; Samuel Oliveira; Leticia Almeida; Augusto V. Gonçalves; Debora B. Perucello; Warrison A. Andrade; Ricardo Castro; Flavio P. Veras; Juliana E. Toller-Kawahisa; Daniele C. Nascimento; Mikhael H.F. de Lima; Camila M.S. Silva; Diego B. Caetite; Ronaldo B. Martins; Italo A. Castro; Marjorie C. Pontelli; Fabio C. de Barros; Natália B. do Amaral; Marcela C. Giannini; Letícia P. Bonjorno; Maria Isabel F. Lopes; Rodrigo C. Santana; Fernando C. Vilar; Maria Auxiliadora-Martins; Rodrigo Luppino-Assad; Sergio C.L. de Almeida; Fabiola R. de Oliveira; Sabrina S. Batah; Li Siyuan; Maira N. Benatti; Thiago M. Cunha; José C. Alves-Filho; Fernando Q. Cunha; Larissa D. Cunha; Fabiani G. Frantz; Tiana Kohlsdorf; Alexandre T. Fabro; Eurico Arruda; Renê D.R. de Oliveira; Paulo Louzada-Junior; Dario S. Zamboni
DOI: 10.1084/jem.20201707
Christina Megli; Stefanie Morosky; Dhivyaa Rajasundaram; Carolyn B. Coyne
DOI: 10.1084/jem.20200649
Jeannette L. Tenthorey; Roberto A. Chavez; Thornton W. Thompson; Katherine A. Deets; Russell E. Vance; Isabella Rauch
DOI: 10.1084/jem.20191736
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