Various chemical and physiological aspects of the reproductive cycles of r+ and r strains of T2, T4, and T6 viruses have been examined and compared. These include the ultraviolet absorption spectra in which differences between r and r+ strains were not observed, though they were obtained in the case of T2, T4, and T6. Adsorption of T4 and T6 was found to require the adsorption cofactor l-tryptophane. Among the r and r+ strains of these viruses limiting tryptophane requirements for adsorption were found to be different. Some differences were observed in the one-step growth curves of these viruses under conditions of single and multiple infection. The turbidity-time relations of infected cultures were characteristically different. The rates of DNA and protein synthesis in the infected cells were found to be independent of the viruses used. Certain implications of the data have been discussed.
Article|
June 01 1950
CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS : VII. A COMPARISON OF SOME PROPERTIES OF THREE MUTANT PAIRS OF BACTERIAL VIRUSES, T2r+ AND T2r, T4r+ AND T4r, T6r+ AND T6r
Seymour S. Cohen,
Seymour S. Cohen
From The Children's Hospital of Philadelphia (Department of Pediatrics) and the Department of Physiological Chemistry, School of Medicine, University of Pennsylvania, Philadelphia
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Rachel Arbogast
Rachel Arbogast
From The Children's Hospital of Philadelphia (Department of Pediatrics) and the Department of Physiological Chemistry, School of Medicine, University of Pennsylvania, Philadelphia
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Seymour S. Cohen
From The Children's Hospital of Philadelphia (Department of Pediatrics) and the Department of Physiological Chemistry, School of Medicine, University of Pennsylvania, Philadelphia
Rachel Arbogast
From The Children's Hospital of Philadelphia (Department of Pediatrics) and the Department of Physiological Chemistry, School of Medicine, University of Pennsylvania, Philadelphia
Received:
January 22 1950
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright, 1950, by The Rockefeller Institute for Medical Research New York
1950
J Exp Med (1950) 91 (6): 619–636.
Article history
Received:
January 22 1950
Citation
Seymour S. Cohen, Rachel Arbogast; CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS : VII. A COMPARISON OF SOME PROPERTIES OF THREE MUTANT PAIRS OF BACTERIAL VIRUSES, T2r+ AND T2r, T4r+ AND T4r, T6r+ AND T6r . J Exp Med 1 June 1950; 91 (6): 619–636. doi: https://doi.org/10.1084/jem.91.6.619
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