In the hypersensitive animal a single inoculation of homologous antigen mixed with Shwartzman preparatory toxin may lead to the production of a Shwartzman reaction which functions as an amplifier of the antigen-antibody tissue response.

The combination of antigen and bacterial toxin does not alter the antigenicity of purified bovine gamma globulin.

This form of the Shwartzman phenomenon may be useful in the investigation of hyperergic tissue reactions.

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Copyright, 1950, by The Rockefeller Institute for Medical Research New York
1950
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