Omission of a single constituent from a chemically defined medium approximating the virus growth-promoting properties of broth affects virus production in infected bacteria. This may be estimated by the one-step growth technique and the course of desoxyribose nucleic acid synthesis. Nine amino acids and one purine have been shown to be important by these tests. A combination of all constituents observed to be important by the single supplement and single omission techniques has approximated the virus growth-promoting properties of broth. Certain anomalous results have been commented upon.
CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS : V. SOME ADDITIONAL METHODS OF DETERMINING NUTRITIONAL REQUIREMENTS FOR VIRUS MULTIPLICATION
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Seymour S. Cohen, Catherine B. Fowler; CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS : V. SOME ADDITIONAL METHODS OF DETERMINING NUTRITIONAL REQUIREMENTS FOR VIRUS MULTIPLICATION . J Exp Med 1 April 1948; 87 (4): 275–282. doi: https://doi.org/10.1084/jem.87.4.275
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