PREPARATION OF THE TYPE-SPECIFIC POLYSACCHARIDE OF THE TYPE I MENINGOCOCCUS AND A STUDY OF ITS EFFECTIVENESS AS AN ANTIGEN IN HUMAN BEINGS

Kabat , Elvin A.; Kaiser , Hilda; Sikorski , Helen

doi:10.1084/jem.80.4.299

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Article| October 01 1944

PREPARATION OF THE TYPE-SPECIFIC POLYSACCHARIDE OF THE TYPE I MENINGOCOCCUS AND A STUDY OF ITS EFFECTIVENESS AS AN ANTIGEN IN HUMAN BEINGS

Elvin A. Kabat,

Elvin A. Kabat

From the Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York

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Hilda Kaiser,

Hilda Kaiser

From the Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York

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Helen Sikorski

From the Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York

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Author and Article Information

Elvin A. Kabat

From the Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York

Hilda Kaiser

From the Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York

Helen Sikorski

From the Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York

Received: July 26 1944

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1944, by The Rockefeller Institute for Medical Research New York

1944

J Exp Med (1944) 80 (4): 299–307.

https://doi.org/10.1084/jem.80.4.299

1. Methods for preparing small amounts of Type I meningococcal polysaccharide which are electrophoretically homogeneous and contain only traces of other immunologically reactive material are given.

2. These polysaccharides are very poor antigens in man but in a small number of instances definite amounts of precipitin and protective antibody were formed.

3. The significance of these findings is discussed.

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Copyright, 1944, by The Rockefeller Institute for Medical Research New York

1944

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PREPARATION OF THE TYPE-SPECIFIC POLYSACCHARIDE OF THE TYPE I MENINGOCOCCUS AND A STUDY OF ITS EFFECTIVENESS AS AN ANTIGEN IN HUMAN BEINGS

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