The reparative process which follows the wide spread necrosis of the dog's liver caused by the injection of hæmagglutinative serum constitutes a chronic interstitial hepatitis of definite and constant character. This is not only a new type of experimental hepatic lesion, but is more definitely a cirrhosis than is any other experimental lesion hitherto described. It is of importance in explaining the histogenesis of cirrhosis, and incidentally various repair processes in the liver; but it does not aid in the elucidation of the etiology of cirrhosis in man, nor does it explain the peculiar arrangement of the new connective tissue in any form of human cirrhosis except possibly that associated with chronic passive congestion. It definitely demonstrates, however, that cirrhosis may follow extensive primary destructive lesions, a view not yet fully accepted, and supports the contention of Kretz that cirrhosis is essentially a reparative process.
Article| January 25 1906
EXPERIMENTAL CIRRHOSIS OF THE LIVER
Richard M. Pearce
From the Bender Laboratory, Albany, N.Y.
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright, 1906, by The Rockefeller Institute for Medical Research New York
J Exp Med (1906) 8 (1): 64–73.
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Richard M. Pearce; EXPERIMENTAL CIRRHOSIS OF THE LIVER . J Exp Med 25 January 1906; 8 (1): 64–73. doi: https://doi.org/10.1084/jem.8.1.64
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