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Electrophoretic studies and erythrocyte sedimentation rate measurements were carried out on normal and pathological human blood. An increase in α globulin levels appears to take place, as well as an increase in sedimentation rates, when there is present any considerable inflammation or tissue destruction, irrespective of its cause. A graphic correlation is presented between sedimentation rates and α globulin levels, which is at least as good as a similar correlation involving fibrinogen levels.

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