Intracerebral inoculation of tuberde bacilli into normal guinea pigs induces acute meningoencephalitis with minor metastatic lesions. The disease is fatal in a relatively short time and is characterized by a rather typical succession of symptoms and a fairly characteristic temperature curve. The disease is produced by very small numbers of bacilli; and under standard conditions, survival time is so uniform as to make possible quantitative or titration experiments. Certain possible applications of the method are discussed.

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