CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : VI. THE SYNTHESIS OF p-AMINOPHENOL α-GLUCOSIDE AND ITS COUPLING WITH PROTEIN

1. The synthesis of p-aminophenol α-glucoside has been described. This glucoside can be coupled to any protein to yield a synthetic α-glucoside-protein complex.

2. A synthetic ß-glucoside-protein complex has also been prepared.

3. These synthetic sugar-protein complexes have been used as immunizing antigens in order to ascertain whether α- and ß-glucosidic unions influence the specificity of the immune response in animals. The results of the immunological studies are presented in the following paper.