1. Vaccine virus and specific immune serum mixed in such proportions as to produce no lesion when inoculated intradermally induce immunity when instilled into the nasal cavities of rabbits.

2. The mixture is also effective when inoculated subcutaneously.

3. Immunity is brought about with a minimum of systemic reaction and no local one.

4. When the mixtures are incompletely neutralized generalized vaccinia results.

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