The temperature reaction in tuberculous and normal guinea pigs and rabbits is elicited by the tuberculo-protein and probably not at all by the polysaccharides. The polysaccharides may have some killing power under certain conditions, but this is not as consistently related to dosage as in the case of the proteins. Both proteins and polysaccharides cause a change in the white blood cells when introduced by any route.
A STUDY OF THE TOXIC PROPERTIES OF TUBERCULO-PROTEINS AND POLYSACCHARIDES
Florence R. Sabin, Franklin R. Miller, Charles A. Doan, Bruce K. Wiseman; A STUDY OF THE TOXIC PROPERTIES OF TUBERCULO-PROTEINS AND POLYSACCHARIDES . J Exp Med 1 January 1931; 53 (1): 51–80. doi: https://doi.org/10.1084/jem.53.1.51
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