1. Typical lethal anaphylactic shock has been produced in guinea pigs by means of the specific carbohydrate derived from a human strain of tubercle bacillus. The phenomenon has been observed in animals both actively and passively sensitized.

2. Typical contractions have been evoked in the isolated uterus of guinea pigs upon the addition of the specific carbohydrate to the bath.

3. True anaphylactic shock against the specific carbohydrate in guinea pigs sensitized with the tubercle bacillus does not prevent or diminish the cutaneous reaction to O. T. in those animals which recover.

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