1. Muscle degeneration was constantly found in the intercostal muscles of scorbutic guinea pigs.
2. It has likewise been found in the masseter and diaphragmatic muscles.
3. Exercise will produce an identical lesion in other skeletal muscles in scorbutic animals.
4. The lesions appear to be an intrinsic part of the scorbutic process.
5. It is suggested that the tenderness over muscles in scorbutic animals and in man may be due to this myopathy.