A localization out of the blood stream of the agent causing a chicken tumor, with the subsequent development of the growth can be brought about in the breast muscle, by inducing in this tissue a reaction by such substances as Scharlach R, tar, embryonic tissue and kieselguhr. Localization in the reaction tissue elicited by kieselguhr takes place relatively infrequently. The earlier stages of the reaction induced by these substances localize the tumor agent more regularly than the later stages of the reaction.

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