The loss of the specialized function of S production by Type II pneumococcus was accompanied by a loss of the antigenic properties involved in both active and passive protection of mice. Absorption of Type II serum with S-producing pneumococci removed all the protective antibodies, as well as the type-specific agglutinins and S precipitins. The same absorption treatment of the serum by non-S-producing pneumococci failed entirely to remove the type-specific antibodies and did not affect the protective value of the serum. Absorption with bacteria-free culture fluids containing the reactive carbohydrate removed the protective antibodies as completely as absorption with the whole bacterial cells of type-specific strains. The results taken as a whole indicate that the antibodies involved in the usual protection of mice against Type II pneumococci are closely related, if not identical, to the specific anticarbohydrate precipitin.
IMMUNOLOGICAL PROPERTIES OF A TYPICAL (S-PRODUCING) AND A DEGRADED (NON-S-PRODUCING) STRAIN OF TYPE II PNEUMOCOCCUS WITH SPECIAL REFERENCE TO PROTECTIVE ANTIBODIES
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Emidio L. Gaspari, William L. Fleming, James M. Neill; IMMUNOLOGICAL PROPERTIES OF A TYPICAL (S-PRODUCING) AND A DEGRADED (NON-S-PRODUCING) STRAIN OF TYPE II PNEUMOCOCCUS WITH SPECIAL REFERENCE TO PROTECTIVE ANTIBODIES . J Exp Med 1 July 1927; 46 (1): 101–111. doi: https://doi.org/10.1084/jem.46.1.101
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