Pneumococcus hemotoxin, an antigenic substance of bacterial origin,is converted by oxidation to a product devoid of hemolytic action. The oxidation product of the hemotoxin may be converted to the original hemolytic substance by reduction, by the anaerobic action of certain bacteria, or by sodium hydrosulfite. The active lysin, or hemotoxin, produced by the reduction of the inactive oxidized extracts is identical with the original, active, reduced hemotoxin; it possesses the same degree of thermolability and is neutralized by the same specific antibody. The inactive products formed by heating the hemotoxin anaerobically cannot be "reactivated" by reducing agents. The immunological significance of these relations will be discussed in a subsequent paper.
Article| August 01 1926
STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : I. PNEUMOCOCCUS HEMOTOXIN.
James M. Neill
From the Department of Bacteriology and Immunology of Harvard University Medical School, Boston.
Received: December 02 1925
Online Issn: 1540-9538
Print Issn: 0022-1007
Copyright, 1926, by The Rockefeller Institute for Medical Research New York
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James M. Neill; STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : I. PNEUMOCOCCUS HEMOTOXIN. . J Exp Med 1 August 1926; 44 (2): 199–213. doi: https://doi.org/10.1084/jem.44.2.199
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