The nature of the relation between the time-drop and antibody formation cannot be stated as yet. It is certain that the physicochemical change in the serum, detected by means of surface tension measurements, is not due directly to the antibody itself. Neither is it due to the direct action of the antigen on the serum, or to a change in the albumin-globulin ratio in this latter. Rather does it appear like antibody formation itself to be due to a tissue activity. Further experiments are being carried out on this subject.
SURFACE TENSION OF SERUM : XIV. CONCERNING THE CHANGE IN SURFACE TENSION OCCURRING AS A RESULT OF IMMUNIZATION.
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P. Lecomte du Noüy, Lillian E. Baker; SURFACE TENSION OF SERUM : XIV. CONCERNING THE CHANGE IN SURFACE TENSION OCCURRING AS A RESULT OF IMMUNIZATION. . J Exp Med 1 July 1925; 42 (1): 9–15. doi: https://doi.org/10.1084/jem.42.1.9
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