An interstitial focal nephritis found in young calves during the 1st or later months of life, associated with or preceded by the invasion of a special, virulent type of Bacillus coli, may be produced by postponing the feeding of colostrum 24 to 36 hours, or by withholding it altogether. In the presence of a virulent type of Bacillus coli few calves completely deprived of colostrum survive the 1st week. Among the survivors, the spotted kidney, the result of Bacillus coli bacteriemia, is frequently encountered. Calves normally fed have not shown the spotted kidney, and such as have been killed early have had uniformly sterile kidneys.

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