The experiments reported here show that the resistance of mice to spontaneous neoplastic diseases can be increased by means of oleic acid injections. This is demonstrated (1) by the greatly reduced incidence of local recurrences at the site of operation, and the lessened incidence (2) of primary tumors developing at other locations, (3) of metastases as encountered at autopsy, and (4) of takes of autoplastic tumor grafts, while finally, (5) there is an appreciable increase of the average postoperative longevity.

Supplementary to the above results is the finding that in the treated mice the reaction about the implanted cancer graft differs from that encountered in untreated animals.

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